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N-Deshydroxyethyl Dasatinib

CAS No. 910297-51-7

N-Deshydroxyethyl Dasatinib( —— )

Catalog No. M33561 CAS No. 910297-51-7

N-Deshydroxyethyl Dasatinib (N-Deshydroxyethyl BMS-354825) is a metabolite of Dasatinib, a dasatinib-based molecule that degrades ABL by binding to the IAP ligand via a linker to form SNIPER.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    N-Deshydroxyethyl Dasatinib
  • Note
    Research use only, not for human use.
  • Brief Description
    N-Deshydroxyethyl Dasatinib (N-Deshydroxyethyl BMS-354825) is a metabolite of Dasatinib, a dasatinib-based molecule that degrades ABL by binding to the IAP ligand via a linker to form SNIPER.
  • Description
    N-Deshydroxyethyl Dasatinib (N-Deshydroxyethyl BMS-354825) is a metabolite of Dasatinib, Dasatinib is a multi-kinase inhibitor that potently inhibits Bcr-Abl, Src family and platelet-derived growth factor receptor kinases. N-Deshydroxyethyl Dasatinib can be used in cancer and immune disease research.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Drug Metabolite | IAP
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    910297-51-7
  • Formula Weight
    443.95
  • Molecular Formula
    C20H22ClN7OS
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 55 mg/mL (123.89 mM; Ultrasonic )
  • SMILES
    N(C1=CC(=NC(C)=N1)N2CCNCC2)C=3SC(C(NC4=C(C)C=CC=C4Cl)=O)=CN3
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Shibata N, et al. Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands. Cancer Sci. 2017 Aug;108(8):1657-1666.?
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